Thanks to ITM, Antwerp, and INSA, Lisbon for the excellent and quick delivery of this information. The “coding region” analysis for both draft sequences shows that there appear to be no differences among these two genomes and the UK, Singaporean, and Israel isolates originated from the 2018 exportation from Nigeria.
For additional granularity, it would be essential to focus sequencing efforts on characterizing the short-tandem repeat areas (located around bases 70-500 and 197600-197200 in MPXV-COG_2003 (Esposito, JJ, et al 2006; Shehelkunov SN, 2002; Wittek R, 1980; Gubser C, 2002; Kugelman, JR, 2014). While these areas of the genome are difficult to analyze and assemble, their very high variability allows for fine granularity and differentiation of very close genomes.