Complete sequence of Orthohantavirus andesense virus: Swiss resident 2026

Thank you for sharing! Had some free time and had a go at making some segment trees.

Brief methods:

  • Downloaded all taxid 1980456 nucleotide sequences
  • Separated by segment and made some preliminary alignments and fasttree phylogenies
  • Manually picked the sequences clustering closest with the new virus and remade proper nucleotide alignments and trees for each segment (alignments: mafft localpair, trees: iqtree2, 10,000 UFbootstraps)

Here’s the trees (closest clade only) for all three segments:

Long story short, looks like a likely spillover from the O. longicaudatus rodent Argentina/Chile natural reservoir from a clade of Andes hantavirus that frequently infects humans.

I summarise the papers that describe the related viruses below:

KC accessions (blue):

Martinez-Valdebenito (2014): https://doi.org/10.3201/eid2010.140353

Human cases in Chile (Note: the sequences on this tree are the “control samples” described in the study and not the ones of the five patients of the outbreak described in the paper; M segment only).

EU accessions (orange):

Medina et al (2009): https://doi.org/10.1128/jvi.01057-08

Naturally infected Oligoryzomys longicaudatus (natural reservoir) from Chile

MN accessions (green):

Martinez et al (2020): https://doi.org/10.1056/NEJMoa2009040

2018-2019 outbreak in humans in Argentina

PV accessions (yellow):

Barrera et al (2025): https://doi.org/10.1016/j.crmicr.2025.100472

2024 outbreak in humans in Chile

OP accessions (grey):

Bellomo et al (2023): https://doi.org/10.1128/msphere.00018-23

Naturally infected Oligoryzomys longicaudatus (natural reservoir) from Argentina

All alignments, trees, and metadata here:

ANDV_summary_080526-spyros.zip (190.9 KB)

Let’s hope no more transmission of this one! :crossed_fingers:

Spyros

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