Following up on this thread, thank you for the rapid response across teams – I have done a preliminary selection analysis (M segment) on available sequences (thank to you the Pathoplexus group for making the data gathering step quicker). After some QC and filtering, selection analysis on an alignment of human and non-human sequences shows pervasive negative selection (~73% of codon sites) in GPC. In my current analysis, I do not find evidence for human-associated adaptation in ANDV GPC.
Further work is needed around sampling scheme and additional selection models. Table showing significant sites/mapping and output JSON files are available:
ANDV_GPC_global_AGL.zip (256.0 KB)