Hi, i use a different method to calculate the mutation rates, I plot Collection Dates versus Mutation numbers relative to the reference using the latest data(445 completed genomes, accessed on March 12), I found the average collection dates(the blue dots) fit very well with mutation numbers. It showed average take 4 days to accumulate one mutation, so the mutation rate is around 90mutations/genome/year, or 3x10-3/site/year. That is quite different with your results. How do you think about this? Thanks.