# Selection analysis of GISAID SARS-CoV-2 data

**URL:** <https://virological.org/t/selection-analysis-of-gisaid-sars-cov-2-data/448>\
**Category:** nCoV-2019 Evolutionary History\
**Created:** [March 27, 2020, 3:17am UTC](https://virological.org/t/selection-analysis-of-gisaid-sars-cov-2-data/448 "2020-03-27T03:17:59Z")\
**Posts on this page:** 1\
**Showing post:** 2

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**Author:** ![sergei.pond](https://virological.org/user_avatar/virological.org/sergei.pond/32/815_2.png) [@sergei.pond](https://virological.org/u/sergei.pond)\
**Post date:** [April 2, 2020, 3:28pm UTC](https://virological.org/t/selection-analysis-of-gisaid-sars-cov-2-data/448/2 "2020-04-02T15:28:58Z")

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April 1st update.

SEVEN (maybe eight) sites currently showing some evidence of selection

- S D614G : has some reversions, toggle-like behavior; HLA/CTL?
- ORF3a Q57H : additional line of evidence – intrahost NGS variation data
- ORF8 84L/S : may be toggling
- ORF1a T265I (nsp2 T85I) : late and multiple introductions (high frequency)
- ORF1a L960F (nsp3 L142F) : late and multiple introductions (low frequency)
- ORF1a L3606F (nsp6 L37F) : additional line of evidence – intrahost NGS variation data
- ORF1b T1729I (exonuclease T206I) : late and multiple introductions (low frequency)
- (Maybe) ORF1a L1599F (nsp3 L781F) : this variant appears to have gone extinct

Details at [http://covid19.datamonkey.org/2020/04/01/covid19-analysis/](http://covid19.datamonkey.org/2020/04/01/covid19-analysis/)

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